Horizon-2020 MSCA RISE Project №778157 CanBioSe: Novel 1D photonic metal oxide nanostructures for early stage cancer detection

CanBioSe

Project ID: 778157 MSCA-RISE-2017 - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) 

The project CanBioSe targeted to strengthen international and intersectoral collaboration, sharing new ideas and knowledge transfer from research to market and vice versa in the field of nanostructured metal oxide optical biosensors for cancer cells detection. Interdisciplinary project research and innovation goals are targeted to develop a new portable tool for early stage cancer detection which can solve on of important health challenges in EU society.

From 2018-01-01 to 2021-12-31

Project details

Total cost:

EUR 1 282 500

EU contribution:

EUR 1 246 500

Coordinated in:

Latvia

Topic(s):

MSCA-RISE-2017 - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) 

Call for proposal:

H2020-MSCA-RISE-2017

Funding scheme:

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Objective

One dimensional (1D) polimer nanofibers will be deposited by electrospinning technique. Photonic nanomaterials, based on metal oxide based nanostructures (ZnO, ZnO/Al2O3 nanolaminates, Au/ZnO and ZnO/Au) will coat the 1D nanofibers. Metal oxides and Au nanoparticles will be deposited with Atomic Layer Deposition (ALD) and electrophoresis, respectively. Bioselective layer will be formed by immobilization of specific antibodies on the biosensor surface. Photoluminescence and optical spectroscopy will be used for recording of the biosensor signal. Biosensor testing will be performed on cancer cells (human chronic lymphocyte leukemia (CLL) leucosis and acute lymphoblastic leucosis). The biosensor will be integrated with microfluidic system in order to minimize dimensions and simplify the use of the detection system.

The project partners will provide research and training activities in the fields of nanotechnology, surface functionalization, bioengineering, microfluidics and biosensor testing, market analysis and commercialization. Provided research and management training to experienced researchers and early stage researchers will strengthen their personal skills and CVs via new scientific papers and conference theses and strengthen a development of EU research human resources. Long lasting collaboration between partners, based on co-supervising students and preparation of novel collaborative project proposals is foreseen. Dissemination of the project results to scientific society and wide auditories is foreseen.

Coordinator

LATVIJAS UNIVERSITATE
RAINIS BOULEVARD 19
1586 RIGA
Latvia
Activity type: Higher or Secondary Education Establishments

EU contribution: EUR 423 000 

Participants:

VILNIAUS UNIVERSITETAS
Lithuania

EU Contribution € 207 000

Address: Universiteto G. 3, 01513 Vilnius

Activity type: Higher or Secondary Education Establishments

 

ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER

France

EU Contribution € 112 500

Address: 240 Av Du Prof Emile Jeanbrau, 34296 Montpellier Cedex 5

Activity type: Higher or Secondary Education Establishments

 

UNIWERSYTET IM. ADAMA MICKIEWICZA W POZNANIU
Poland

EU Contribution € 333 000

Address: Ul. Henryka Wieniawskiego 1, 61712 Poznan

Activity type: Higher or Secondary Education Establishments

 

FONDAZIONE BRUNO KESSLER
Italy

EU Contribution € 36 000

Address: Via Santa Croce 77, 38122 Trento

Activity type: Research Organisations

 

EESTI MATERJALITEHNOLOOGIATE ARENDUSKESKUSE OÜ
Estonia

EU Contribution: € 58 500

Address: Teaduspargi Tn 13, 51014 Tartu

Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)

 

BIOSENSOR SRL
Italy

EU Contribution: € 49 500

Address: Via Degli Olmetti 44, 00060 Formello

Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)

 

NANOPHARMA AS
Czechia

EU Contribution € 63 000

Address: Nova 306, 530 09 Pardubice

Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)

 

MATERIALS RESEARCH CENTRE
Ukraine

EU Contribution € 49 500

Address: Yaroslaviv Val/Olesya Honchara

Activity type: SME

 

PARTNER:

Institute of Biophysics and Cell Engineering, National Academy of Sciences of Belarus
Belarus

Address: Akademicheskaya 27, 220072 Minsk

Activity type: Research Organisations

https://cordis.europa.eu/project/rcn/213008/factsheet/en

 CanBioSe project news:
 

Horizon 2020 CANBIOSE project participant from MRC Ivan Hryshko completed secondment visit to Vilnius University, Lithuania, on February-March 2020

altHe made a presentation at a seminar to share knowledge and experience in MAX phase and MXene synthesis, received a training and also worked with colleagues from VU on nanomaterials characterization, all related issues were discussed with project participants from Vilnius University.


 
 

 

CanBioSe project Meeting and Workshop atinternational Conference  on Nanomaterials for biosensors and nanomedical applications in Yurmala, Latvia, July 2019  

altMRC representatives, Oleksiy Gogotsi and Veronika Zahorodna attended CanBioSe project meeting held during International Conference on Nanomaterials for biosensors and biomedical applications, Jurmala, Latvia, on July 2019.

 
 

Project Meeting and Workshop under Horizon-2020 MSCA RISE CanBioSE project, 17-18 th of April 2019, Vilnius, Lithuania

altResearch team of Materials Research Centre led by Oleksiy Gogotsi take part in CanBioSe project meeting and Workshop held in Vilnius University, Vilnus, Lithuania. MRC team met with another CanBioSe project participants, presented MRC company. Also MRC director gave a talk on 2d materials MXenes and their possible applications.

 

 

 
 

News from MRC.ORG.UA

2024 MRS Fall Meeting & Exhibit, Boston, Massachusetts, from December 1-6, 2024

2024 MRS Fall Meeting & Exhibit, Poster Session, from left to right: Prof. Yury Gogotsi, Prof. Maksym Pogorielov, Prof. Goknur Buke, Dr. Babak Anasori and Dr. Oleksiy GogotsiDr. Oleksiy Gogotsi, director of MRC and Carbon-Ukraine, innovative companies that are among the leaders on the world MXene market, visited 2024 MRS Fall Meeting & Exhibit. together with Dr. Maksym Pogorielov, Head of Advanced Biomaterials and Biophysics Laboratory, University of Latvia.

 
Our team participated in the 3rd International Conference at Drexel University "MXene: Changing the World", August 5-7, 2024

3rd international MXene Confernce at Drexel University, August 5-7, 2024, Philadelphia, USAMRC and Carbon-Ukraine team visited the 3rd International MXene conference held at Drexel University on August 5-8, 2024. Conference brought together the best reserchers and leading experts on MXene field. 

 
Visit to our project partners from Worcester Polytechnic Institute that joined to ESCULAPE research project consortium

Visiting Functional Biomaterials Lab at Worcester Polytechnic Institute led by Dr. Jeannine Coburne

Looking forward to work together with Dr. Lyubov Titova and Dr. Jeannine Coubourne from Worcester Polytechnic Institute on structural and biomedical applications of MXenes and study of their properties within HORIZON EUROPE MSCA RISE ESCULAPE project!

 
MXenes for biomedical applications: MXene-Polydopamine-antiCEACAM1 Antibody Complex as a Strategy for Targeted Ablation of Melanoma

MXene-Polydopamine-antiCEACAM1 Antibody Complex fro cancer therapyTogether with colleagues from the University of Latvia, MRC/Carbone Ukraine, Adam Mickiewicz University, University Clinic Essen, and others, we have developed a novel concept involving the binding of antibodies to MXenes. In our research, we utilized anti-CEACAM1 antibodies to develop targeted photo-thermal therapy for melanoma (in vitro), paving the way for future in vivo studies and clinical trials. For the first time, we demonstrate the feasibility of delivering MXenes specifically targeted to melanoma cells, enabling the effective ablation of cancer cells under near-infrared (NIR) light. This new technique opens up vast potential for the application of MXenes in cancer treatment, diagnostics, drug delivery, and many other medical purposes.

 
Looking forward our collaboration with Dr. Vladimir Tsukruk's team from Georgia Tech University in trilateral research project IMPRESS-U on MXene-Based Composite Bio-membranes with Tailored Properties

SSU, MRC and Carbon-Ukraine team visited research group led by Prof. Vladimir Tsukruk from Georgia Tech University, Atlanta, USA

Looking forward our collaboration with Dr. Vladimir Tsukruk's team from Georgia Tech University in trilateral research project IMPRESS-U, involving teams from Ukraine, Latvia, and the United States funded by National Science Foundation (NSF). project is focused on MXene-Based Composite Bio-membranes with Tailored Properties. Can't wait our Kick-off meeting that will be held at Latvias University in Riga with all project participants.

 

 
Our new collaborative research paper with Drexel team on Porous Ti3AlC2 MAX phase enables efficient synthesis of Ti3C2Tx MXene

porous MAX phase technologyIn this study, we have optimized the synthesis of MAX phases for MXene manufacturing. The main purpose of this study is to develop a porous Ti3AlC2MAX phase that can be easily ground into individual grains manually without time-consuming eliminating the need for drilling and intenseball-milling before MXene synthesis. Moreover, we also demonstrate the synthesis of highly porous Ti3AlC2 (about 70%) from an inexpensive raw materials.

 
Novel electrically conductive electrospun PCL‑MXene scaffolds for cardiac tissue regeneration

Scanning electron microscopy image of PCLMXene membranes crosssection (left side) with the representation of EDX line (dotted line) and example of cross-sectional EDX elements line scan (right side)Here we demonstrate a new developed method for depositing Ti3C2Tx MXenes onto hydrophobic electrospun PCL membranes using oxygen plasma treatment. These novel patches hold tremendous potential for providing mechanical support to damaged heart tissue and enabling electrical signal transmission,thereby mimicking the crucial electroconductivity required for normal cardiac function. After a detailed investigation of scaffold-to-cell interplay, including electrical stimulation, novel technology has the potential for clinical application not only for cardiac regeneration, but also as neural and muscular tissue substitutes.

 
Read recently published paper about our collaborative work: MXene Functionalized Kevlar Yarn via Automated, Continuous Dip Coating

MXene Functionalized Kevlar Yarn via Automated,Continuous Dip CoatingThe rise of the Internet of Things has spurred extensive research on integrating conductive materials into textiles to turn them into sensors, antennas, energy storage devices, and heaters. MXenes, owing to their high electrical conductivity and solution processability, offer an efficient way to add conductivity and electronic functions to textiles. Here, a versatile automated yarn dip coater tailored for producing continuously high-quality MXene-coated yarns and conducted the most comprehensive MXene-yarn dip coating study to date is developed. 

 
MX-MAP project secondment visit of Dr. Oleksiy Gogotsi and Veronika Zahorodna from MRC to University of Padova, Italy, October 2023

altMX-MAP project participants from MRC Dr. Oleksiy Gogotsi and Veronika Zahorodna performed split secondment visit to project partner organization University of Padova (Italy). MX-MAP project works on development of the key strategies for MXene medical applications. 

 
CanbioSe Project Meeting and Project Workshop, September 26-27, 2023, Montpellier, France

altCanbioSe Project Meeting and Project Workshop was held  at European Institute of Membranes (IEM), University of Montpellier, France on September 26-27, 2023. The workshop was focused on the theme of "Commercializing Biosensors, Intellectual Property, and Knowledge Transfer from Academia to Industry.

 
IEEE NAP 2023: 2023 IEEE 13th International Conference “Nanomaterials: Applications & Properties” Sep 10, 2023 - Sep 15, 2023, Bratislava, Slovakia

altDr. Oleksiy Gogotsi and Veronika Zahorodna visited IEEE NAP 2023 conference held in Bratislava on September 10-15, 2023. The prime focus of the IEEE NAP-2023 was on nanoscale materials with emphasis on interdisciplinary research exploring and exploiting their unique physical and chemical proprieties for practical applications.

 
Visit to CEST labs in Wiener Neustadt (Low Energy Ion Scattering, Batteries development) and TU Vienna (ELSA, SFA)

altDirector of MRC and Carbon-Ukraine Dr. Oleksiy Gogotsi visited CEST labs in Wiener Neustadt (Low Energy Ion Scattering, Batteries development) and TU Vienna (ELSA, SFA). He meet with Dr. Pierluigi Bilotto, Dr. Chriatian Pichler and their colleagues, discussing novel materials and r&d activities for new technologies.

 
MX-MAP Session at YUCOMAT Conference 2023 "Towards MXenes’ biomedical applications by high-dimensional immune MAPping", HORIZON-MSCA-2021-SE-01 project MX-MAP.

altMX-MAP Session was held during the YUCOMAT Conference 2023 titled: "Towards MXenes’ biomedical applications by high-dimensional immune MAPping", HORIZON-MSCA-2021-SE-01 project MX-MAP.

 
THE TWENTY-FOURTH ANNUAL CONFERENCE YUCOMAT 2023, HERCEG NOVI, MONTENEGRO, September 04-08, 2023

altThe conference was organised by the Materials Research Society of Sebia and supported by MRS-Singapore with the participation of a pleiad of distinguished scientists.

 
CANBIOSE secondment visit of Dr. Oleksiy Gogotsi and Veronika Zahorodna from MRC to European Institute of Membranes in Montpellier, France

altCANBIOSE project participants from MRC Dr. Oleksiy Gogotsi and Veronika Zahorodna performed secondment visit to project partner organization European Institute of Membranes in Montpellier (France) on August -September 2023.