Horizon-2020 MSCA RISE Project №778157 CanBioSe: Novel 1D photonic metal oxide nanostructures for early stage cancer detection

CanBioSe

Project ID: 778157 MSCA-RISE-2017 - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) 

CANBIOSE project Horizon 2020The project CanBioSe targeted to strengthen international and intersectoral collaboration, sharing new ideas and knowledge transfer from research to market and vice versa in the field of nanostructured metal oxide optical biosensors for cancer cells detection. Interdisciplinary project research and innovation goals are targeted to develop a new portable tool for early stage cancer detection which can solve on of important health challenges in EU society.

From 2018-01-01 to 2021-12-31

Project details

Total cost:

EUR 1 282 500

EU contribution:

EUR 1 246 500

Coordinated in:

Latvia

Topic(s):

MSCA-RISE-2017 - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) 

Call for proposal:

H2020-MSCA-RISE-2017

Funding scheme:

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Objective

One dimensional (1D) polimer nanofibers will be deposited by electrospinning technique. Photonic nanomaterials, based on metal oxide based nanostructures (ZnO, ZnO/Al2O3 nanolaminates, Au/ZnO and ZnO/Au) will coat the 1D nanofibers. Metal oxides and Au nanoparticles will be deposited with Atomic Layer Deposition (ALD) and electrophoresis, respectively. Bioselective layer will be formed by immobilization of specific antibodies on the biosensor surface. Photoluminescence and optical spectroscopy will be used for recording of the biosensor signal. Biosensor testing will be performed on cancer cells (human chronic lymphocyte leukemia (CLL) leucosis and acute lymphoblastic leucosis). The biosensor will be integrated with microfluidic system in order to minimize dimensions and simplify the use of the detection system.

The project partners will provide research and training activities in the fields of nanotechnology, surface functionalization, bioengineering, microfluidics and biosensor testing, market analysis and commercialization. Provided research and management training to experienced researchers and early stage researchers will strengthen their personal skills and CVs via new scientific papers and conference theses and strengthen a development of EU research human resources. Long lasting collaboration between partners, based on co-supervising students and preparation of novel collaborative project proposals is foreseen. Dissemination of the project results to scientific society and wide auditories is foreseen.

Coordinator

LATVIJAS UNIVERSITATE
RAINIS BOULEVARD 19
1586 RIGA
Latvia
Activity type: Higher or Secondary Education Establishments

EU contribution: EUR 423 000 

Participants:

VILNIAUS UNIVERSITETAS
Lithuania

EU Contribution € 207 000

Address: Universiteto G. 3, 01513 Vilnius

Activity type: Higher or Secondary Education Establishments

 

ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER

France

EU Contribution € 112 500

Address: 240 Av Du Prof Emile Jeanbrau, 34296 Montpellier Cedex 5

Activity type: Higher or Secondary Education Establishments

 

UNIWERSYTET IM. ADAMA MICKIEWICZA W POZNANIU
Poland

EU Contribution € 333 000

Address: Ul. Henryka Wieniawskiego 1, 61712 Poznan

Activity type: Higher or Secondary Education Establishments

 

FONDAZIONE BRUNO KESSLER
Italy

EU Contribution € 36 000

Address: Via Santa Croce 77, 38122 Trento

Activity type: Research Organisations

 

EESTI MATERJALITEHNOLOOGIATE ARENDUSKESKUSE OÜ
Estonia

EU Contribution: € 58 500

Address: Teaduspargi Tn 13, 51014 Tartu

Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)

 

BIOSENSOR SRL
Italy

EU Contribution: € 49 500

Address: Via Degli Olmetti 44, 00060 Formello

Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)

 

NANOPHARMA AS
Czechia

EU Contribution € 63 000

Address: Nova 306, 530 09 Pardubice

Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)

 

MATERIALS RESEARCH CENTRE
Ukraine

EU Contribution € 49 500

Address: Yaroslaviv Val/Olesya Honchara

Activity type: SME

 

PARTNER:

Institute of Biophysics and Cell Engineering, National Academy of Sciences of Belarus
Belarus

Address: Akademicheskaya 27, 220072 Minsk

Activity type: Research Organisations

https://cordis.europa.eu/project/rcn/213008/factsheet/en

 CanBioSe project news:
 

Horizon 2020 CANBIOSE project participant from MRC Ivan Hryshko completed secondment visit to Vilnius University, Lithuania, on February-March 2020

altHe made a presentation at a seminar to share knowledge and experience in MAX phase and MXene synthesis, received a training and also worked with colleagues from VU on nanomaterials characterization, all related issues were discussed with project participants from Vilnius University.


 
 

 

CanBioSe project Meeting and Workshop atinternational Conference  on Nanomaterials for biosensors and nanomedical applications in Yurmala, Latvia, July 2019  

altMRC representatives, Oleksiy Gogotsi and Veronika Zahorodna attended CanBioSe project meeting held during International Conference on Nanomaterials for biosensors and biomedical applications, Jurmala, Latvia, on July 2019.

 
 

Project Meeting and Workshop under Horizon-2020 MSCA RISE CanBioSE project, 17-18 th of April 2019, Vilnius, Lithuania

altResearch team of Materials Research Centre led by Oleksiy Gogotsi take part in CanBioSe project meeting and Workshop held in Vilnius University, Vilnus, Lithuania. MRC team met with another CanBioSe project participants, presented MRC company. Also MRC director gave a talk on 2d materials MXenes and their possible applications.

 

 

 
 

News from MRC.ORG.UA

Paper on Electrochemically synthesized MXenes as sustainable solid lubricants: Mechanistic insights into tribofilm formation and interfacial dynamics

Electrochemically synthesized MXenes as sustainable solid lubricants. DOI:10.1016/j.carbon.2025.121136Highlights
• First application report on bubble-assisted sustainable EC-MXene
• EC-MXene keeps tribological performance with with mainly O-terminations
• EC-MXene forms a stable tribofilm, supported by experiments and DFT

 
Our team visited Innovative & Industrial 2D/Advanced Materials Summit & Expo I2DM 2025 at Khalifa University in Abu-Dhabi, November 2025

Innovative & Industrial 2D/Advanced Materials Summit & Expo (I2DM2025)We are excited to share that our Carbon-Ukraine (Y-Carbon LLC) company participated in the I2DM Summit and Expo 2025 at Khalifa University in Abu-Dhabi! Huge thanks to Research & Innovation Center for Graphene and 2D Materials (RIC2D) for hosting such a high-level event.It was an incredible opportunity to meet brilliant researchers and innovators working on the next generation of 2D materials. The insights and energy from the summit will definitely drive new ideas in our own development.

 
Carbon-Ukraine team had the unique opportunity to visit XPANCEO - a Dubai-based deep tech startup

Visit to XPANCEOCarbon-Ukraine team had the unique opportunity to visit XPANCEO - a Dubai-based deep tech startup company that is developing the first smart contact lenses with AR vision and health monitoring features, working on truly cutting-edge developments.

 
Our Carbon-Ukraine team (Y-Carbon LLC) are thrilled to start a new RIC2D project MX-Innovation in collaboration with Drexel University Yury Gogotsi and Khalifa University!

Kick off meeting at Khalifa University on  MX-Innovation project funded by RIC2D programOur Carbon-Ukraine team (Y-Carbon LLC) are thrilled to start a new RIC2D project MX-Innovation in collaboration with Drexel University Yury Gogotsi and Khalifa University! Amazing lab tours to project collaborators from Khalifa University, great discussions, strong networking, and a wonderful platform for future collaboration.

 
MXene-based electrochemical glucose biosensors: Comparative enhancement with Aquivion and Nafion

Schematic representation of working electrode development and electrochemical measurement of glucose concentrationThis work provides valuable insights into the use of pristine Ti₃C₂Tₓ MXenes (rather than composites) as promising materials for next-generation glucose biosensors. The study underscores the importance of surface chemistry, film stability, and polymer optimization in achieving high-performance sensing platforms. 

 
Engineering Safer MXenes for Biomedical Applications: Effects of Etching and Delamination on Biocompatibility of Ti-Based MXenes

MXenes for biomedical useMXenes potential applications include sensors, wound healing materials, and drug delivery systems. A recent study explored how different synthesis methods affect the safety and performance of MXenes. By comparing etching conditions and intercalation strategies, researchers discovered that fine-tuning the surface chemistry of MXenes plays a crucial role in improving biocompatibility. These results provide practical guidelines for developing safer MXenes and bring the field one step closer to real biomedical applications.

 
2D MXenes in the Design of Heavy Metal Ion Sensors

2D MXenes in the design of heavy metal ion sensorsAn excellent review highlighting how MXene-based sensors can help tackle one of today’s pressing environmental challenges — heavy metal contamination. Excited to see such impactful work moving the field of environmental monitoring and sensor technology forward!

 
RIC2D MX-Innovation project on MXene production for water desalination and medical diagnostics takes off — Ukraine-based MXene manufacturing company Carbon-Ukraine (Y-Carbon LLC) on board!

MXene Carbon-Ukraine company in MX-Innovation project RIC2D with Dreexl University and Khakifa University

Carbon-Ukraine team is very exited to particpate in newly launched "MX-Innovation" three-year multinational collaboration project led by Prof. Yury Gogotsi, Drexel University (USA) to produce MXene nanomaterials. The project, which is a collaboration with Drexel University USA, Kalifa University in the UAE, the University of Padua in Italy and the Kyiv, Ukraine-based MXene manufacturing company Carbon-Ukraine, seeks to use MXene for water desalination and medical diagnostics. 

 
Carbon-Ukraine team was truly delighted to take part in the kickoff meeting of the ATHENA Project organized by CREST at NATO HQ

Project meeting at NATO HQ, Brussel, BelgiumCarbon-Ukraine team was truly delighted to take part in the kickoff meeting of the ATHENA Project (Advanced Digital Engineering Methods to Design MXene-based Nanocomposites for Electro-Magnetic Interference Shielding in Space), supported by NATO through the Science for Peace and Security Programme.

 
Joint patent application MRC, Carbon-Ukraine and Drexel University on highly porous MAX phase precursor for MXene synthesis published!

altExellent news, our joint patent application with Drexel University on highly porous MAX phase precursor for MXene synthesis published. Congratulations and thanks to all team involved!

 
MXene Symposium "The MXene Frontier: Transformative Nanomaterials Shaping the Future", IEEE NAP-2025 International Conference Bratislava, September 7-12, 2025

MXene Symposium 2025 in BratislavaOur team was very delighted to take part in International Symposium "The MXene Frontier: Transformative Nanomaterials Shaping the Future" – the largest MXene event in Europe this year!  

 
Join us at the IEEE NAP-2025 International Symposium on "The MXene Frontier: Transformative Nanomaterials Shaping the Future", Bratislava, September 7-12, 2025

MXene Symposium 2025 in BratislavaLast Call! Have you submitted your abstract for IEEE NAP-2025 yet? Join us at the International Symposium on "The MXene Frontier: Transformative Nanomaterials Shaping the Future" – the largest MXene-focused conference in Europe this year!  Final Submission Deadline: May 15, 2025. Don’t miss this exclusive opportunity to showcase your research and engage with world leaders in the MXene field!

 
New Publication Alert: "MXenes in Healthcare: Transformative Applications and Challenges in Medical Diagnostics and Therapeutics"

MXene in healthcareWe are excited to announce the publication of latest review article on MXenes in Healthcare. This comprehensive review explores the groundbreaking role of MXenes—an emerging class of 2D materials—in revolutionizing the fields of medical diagnostics and therapeutics.  Read the full article here: https://doi.org/10.1039/D4NR04853A.

 
Pulsed Electrochemical Exfoliation for an HF-Free Sustainable MXene Synthesis

Electrochemical etching of Ti 3 AlC 2 pellet electrodes in aqueous electrolytes: Set-up and workflow with schematic mechanisms to generatedelaminated EC-MXene flakesCongratulations and thank you to our collaborators from TU Wien and CEST for very interesting work and making it published! In this work, an upscalable electrochemical MXene synthesis is presented. Yields of up to 60% electrochemical MXene (EC-MXene) with no byproducts from a single exfoliation cycle are achieved.

 
Elucidation of Potential Genotoxicity of MXenes Using a DNA Comet Assay

Potential Genotoxicity of MXenes Using a DNA Comet Assay. ACS Appl. Bio Mater. 2024, 7, 12, 8351-8366Congratulations to all collaborators with this interesting joint work!

 MXenes are among the most diverse and prominent 2D materials. They are being explored in almost every field of science and technology, including biomedicine. Despite their proven biocompatibility and low cytotoxicity, their genotoxicity has not been addressed, so we investigated whether MXenes interfere with DNA integrity in cultured cells and examined the fragmentation of their chromosomal DNA by a DNA comet assay.