CanBioSe project meeting and workshop at International Conference on Nanomaterials for biosensors and biomedical applications, Jurmala, Latvia

International Conference on Nanomaterials for biosensors and biomedical applications, Jurmala, Latvia

MRC representatives, Oleksiy Gogotsi and Veronika Zahorodna attended CanBioSe project meeting held during International Conference on Nanomaterials for biosensors and biomedical applications, Jurmala, Latvia, on July 2019.

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MRC director Oleksiy Gogotsi made an oral presentaion on MXenes for biosensors and biomedical applications.

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MXenes for biosensors and biomedical applications

Oleksiy Gogotsi^{a, b}, Veronika Zahorodna^{a, b}, Vitalii Balitskyi^a,, Mykola Seredych ^c, Qi Zhao ^c, Yury Gogotsi ^c

^a Materials Research Centre, Kyiv 03680, Ukraine

b National Metallurgical Academy of Ukraine, Dnipro 49600, Ukraine

^cDepartment of Materials Science & Engineering and A.J. Drexel Nanomaterials Institute, Drexel University, Philadelphia, Pennsylvania 19104, United States

2-Dimensional transition metal carbides and nitrides (MXenes) - discovered at Drexel University [1] hold tremendous potential as new materials for biomedial applications. MXenes are produced by selective etching of the A elements (mostly Al) from their ternary layered 3D M_n+1AX_n, phase counterparts, where M is an early transition metal, A is an A-group element, X is C and/or N, and n = 1 to 3 [2]. In contrast to raw M_n+1AX_n phases, the MXene sheets are oxygenated (═O, −OH) and fluorinated (–F) for preferential sorption of target biomolecules. Beyond the characteristics shared by all 2D materials, MXenes stand out in several ways. They are: i) conductive, with high density of states at the Fermi level and metal-like carrier densities; ii) hydrophilic, and thus processable in eco-friendly and sustainable ways; iii) extraordinarily and readily tailorable at multiple levels. MXenes have already shown promising performance in many applications includingdrug delivery and photothermal therapy [3], antibacterial activity [4], electrodes and sensors for medicine [5, 6],selective sorption of small molecules such as urea removal in wearable dialysis systems [7]. Moreover, cytotoxic tests show no significant effect on cell viability during 24 h incubation with 3T3 fibroblast cells by the titanium carbide MXenes [7]. This kind of MXenes sorbents offer open accessible surfaces fully available for proteins and can also be used in treatment of a broad range of conditions ranging from radiation disease and drug overdose to Ebola, Crohn’s disease, Ankylosing Spondylitis and other conditions related to cytokines or toxin in blood.

References

[1] M. Naguib, et al. Two-dimensional nanocrystals produced by exfoliation of Ti₃AlC₂. Advanced Materials 2011, 23, 4248.

[2] B. Anasori, et al. 2D metal carbides and nitrides (MXenes) for energy storage. Nature Review Materials 2017, 16098, 1.

[3] C. Dai, et al. Two-dimensional tantalum carbide (MXenes) composite nanosheets for multiple imaging-guided photothermal tumor ablation. ACS Nano 2017, 11, 12696.

[4] K.Rasool, et al. Antibacterial activity of Ti₃C₂T_x MXene. ACS Nano 2016, 10, 3674.

[5] N. Driscoll, et al. Two-dimensional Ti₃C₂ MXene for high-resolution neural interfaces

ACS Nano 2018, 12, 1041.

Abstract book of the Conference

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