HORIZON Europe MX-MAP project #101086184: Towards MXenes’ biomedical applications by high-dimensional immune MAPping

MX-MAP: Towards MXenes’ biomedical applications by high-dimensional immune MAPping

From 2022-01-01 to 2026-10-31

Project details

Total cost:

EUR 1 389 200

EU contribution:

EUR 1 389 200

Coordinated in:

Italy

Topic(s):

MSCA-RISE-2021 - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) 

Call for proposal:

HORIZON-MSCA-2021-SE-01

Funding scheme:

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

General description and objective

Innovative biomedical applications of MXenes nanomaterials MXenes are a new family of recently discovered 2D transition metal carbides, carbonitrides, and nitrides. The immune characterisation of the new materials on the basis of their physical-chemical and immunological properties will open up perspectives for the development of new therapeutic applications of nanomaterials in tissue engineering, cancer therapy, as antibacterial agents, and as immunomodulators. Funded by the Marie Skłodowska-Curie Actions programme, the MX-MAP project will develop key strategies for MXene medical applications. The long-term goal of MX-MAP is to create a pipeline using new MXene nanomaterials for the qualitative and quantitative assessment of immunological compatibility in biomedical applications. This international research/training programme aims to support the career development of young researchers with an interdisciplinary vision of science.

The long-term goal of MX-MAP is to develop a functional pipeline for the immune characterization of new 2D nanomaterials of MXene family, for the qualitative and quantitative assessment of the human immune compatibility and immune activity towards biomedical applications. The immune characterization of the tested materials on the basis of intrinsic physical-chemical and immunological properties, through the combination of the most innovative technologies such as single-cell mass cytometry (CyTOF), will open breakthrough perspectives for the development of new therapeutic approaches applying nanomaterials as immunomodulators, scaffolds for tissue engineering, cancer therapy, and antibacterial agents.

MX-MAP will develop key chemistry and immune-based strategies for MXene medical applications. The implication of this project extends beyond the specific nanoscience program greatly advancing the engineering process of 2D materials and their use in biomedicine.

The MX-MAP project involves fourteen key players in European and non-European countries, including the United States, Canada, Saudi Arabia, and three partners from Ukraine, coming from academia and SMEs. This program will provide strong support for the development of the careers of young brilliant scientists who want to grow towards an interdisciplinary vision of Science. Chemistry, biology, immunology, engineering, and cancer research are the expertise of MX-MAP. The senior team members are among the most influential scientists, including Prof. Yury Gogotsi (H-index=168) - inventor of MXenes, Prof. Klaus Ley (H-index=147) - one of the most cited immunologists worldwide, and Prof. Husam N Alshareef (H-index=99). The Consortium is perfectly balanced in terms of equal gender presence; the project Coordinator Lucia Gemma Delogu is a female, and 2 out 4 of four WP leaders are female. The project embraces a large view of inclusiveness and diversity, including countries with smaller economies such as Ukraine.

Coordinator

UNIVERSITA DEGLI STUDI DI PADOVA
Via 8 febbraio 2, 35122 Padova, Italy

alt

Recent news about MX-MAP project implementation:

MX-MAP Session at YUCOMAT Conference 2023 "Towards MXenes’ biomedical applications by high-dimensional immune MAPping", HORIZON-MSCA-2021-SE-01 project MX-MAP.

altMX-MAP Session was held during the YUCOMAT Conference 2023 titled: "Towards MXenes’ biomedical applications by high-dimensional immune MAPping", HORIZON-MSCA-2021-SE-01 project MX-MAP.

 

 

Launching HORIZON-MSCA-2021-SE-01 MX-MAP Project: Towards MXenes biomedical applications by high-dimensional immune MAPping

MX-MAP project Meeting during the MXene international conference held in Drexel University on Aug. 3,  2022, and discussing the roadmap for launching MX-MAP research project on MXenes for medical applications.

 

 

 

News from MRC.ORG.UA

2024 MRS Fall Meeting & Exhibit, Boston, Massachusetts, from December 1-6, 2024

2024 MRS Fall Meeting & Exhibit, Poster Session, from left to right: Prof. Yury Gogotsi, Prof. Maksym Pogorielov, Prof. Goknur Buke, Dr. Babak Anasori and Dr. Oleksiy GogotsiDr. Oleksiy Gogotsi, director of MRC and Carbon-Ukraine, innovative companies that are among the leaders on the world MXene market, visited 2024 MRS Fall Meeting & Exhibit. together with Dr. Maksym Pogorielov, Head of Advanced Biomaterials and Biophysics Laboratory, University of Latvia.

 
Our team participated in the 3rd International Conference at Drexel University "MXene: Changing the World", August 5-7, 2024

3rd international MXene Confernce at Drexel University, August 5-7, 2024, Philadelphia, USAMRC and Carbon-Ukraine team visited the 3rd International MXene conference held at Drexel University on August 5-8, 2024. Conference brought together the best reserchers and leading experts on MXene field. 

 
Visit to our project partners from Worcester Polytechnic Institute that joined to ESCULAPE research project consortium

Visiting Functional Biomaterials Lab at Worcester Polytechnic Institute led by Dr. Jeannine Coburne

Looking forward to work together with Dr. Lyubov Titova and Dr. Jeannine Coubourne from Worcester Polytechnic Institute on structural and biomedical applications of MXenes and study of their properties within HORIZON EUROPE MSCA RISE ESCULAPE project!

 
MXenes for biomedical applications: MXene-Polydopamine-antiCEACAM1 Antibody Complex as a Strategy for Targeted Ablation of Melanoma

MXene-Polydopamine-antiCEACAM1 Antibody Complex fro cancer therapyTogether with colleagues from the University of Latvia, MRC/Carbone Ukraine, Adam Mickiewicz University, University Clinic Essen, and others, we have developed a novel concept involving the binding of antibodies to MXenes. In our research, we utilized anti-CEACAM1 antibodies to develop targeted photo-thermal therapy for melanoma (in vitro), paving the way for future in vivo studies and clinical trials. For the first time, we demonstrate the feasibility of delivering MXenes specifically targeted to melanoma cells, enabling the effective ablation of cancer cells under near-infrared (NIR) light. This new technique opens up vast potential for the application of MXenes in cancer treatment, diagnostics, drug delivery, and many other medical purposes.

 
Looking forward our collaboration with Dr. Vladimir Tsukruk's team from Georgia Tech University in trilateral research project IMPRESS-U on MXene-Based Composite Bio-membranes with Tailored Properties

SSU, MRC and Carbon-Ukraine team visited research group led by Prof. Vladimir Tsukruk from Georgia Tech University, Atlanta, USA

Looking forward our collaboration with Dr. Vladimir Tsukruk's team from Georgia Tech University in trilateral research project IMPRESS-U, involving teams from Ukraine, Latvia, and the United States funded by National Science Foundation (NSF). project is focused on MXene-Based Composite Bio-membranes with Tailored Properties. Can't wait our Kick-off meeting that will be held at Latvias University in Riga with all project participants.

 

 
Our new collaborative research paper with Drexel team on Porous Ti3AlC2 MAX phase enables efficient synthesis of Ti3C2Tx MXene

porous MAX phase technologyIn this study, we have optimized the synthesis of MAX phases for MXene manufacturing. The main purpose of this study is to develop a porous Ti3AlC2MAX phase that can be easily ground into individual grains manually without time-consuming eliminating the need for drilling and intenseball-milling before MXene synthesis. Moreover, we also demonstrate the synthesis of highly porous Ti3AlC2 (about 70%) from an inexpensive raw materials.

 
Novel electrically conductive electrospun PCL‑MXene scaffolds for cardiac tissue regeneration

Scanning electron microscopy image of PCLMXene membranes crosssection (left side) with the representation of EDX line (dotted line) and example of cross-sectional EDX elements line scan (right side)Here we demonstrate a new developed method for depositing Ti3C2Tx MXenes onto hydrophobic electrospun PCL membranes using oxygen plasma treatment. These novel patches hold tremendous potential for providing mechanical support to damaged heart tissue and enabling electrical signal transmission,thereby mimicking the crucial electroconductivity required for normal cardiac function. After a detailed investigation of scaffold-to-cell interplay, including electrical stimulation, novel technology has the potential for clinical application not only for cardiac regeneration, but also as neural and muscular tissue substitutes.

 
Read recently published paper about our collaborative work: MXene Functionalized Kevlar Yarn via Automated, Continuous Dip Coating

MXene Functionalized Kevlar Yarn via Automated,Continuous Dip CoatingThe rise of the Internet of Things has spurred extensive research on integrating conductive materials into textiles to turn them into sensors, antennas, energy storage devices, and heaters. MXenes, owing to their high electrical conductivity and solution processability, offer an efficient way to add conductivity and electronic functions to textiles. Here, a versatile automated yarn dip coater tailored for producing continuously high-quality MXene-coated yarns and conducted the most comprehensive MXene-yarn dip coating study to date is developed. 

 
MX-MAP project secondment visit of Dr. Oleksiy Gogotsi and Veronika Zahorodna from MRC to University of Padova, Italy, October 2023

altMX-MAP project participants from MRC Dr. Oleksiy Gogotsi and Veronika Zahorodna performed split secondment visit to project partner organization University of Padova (Italy). MX-MAP project works on development of the key strategies for MXene medical applications. 

 
CanbioSe Project Meeting and Project Workshop, September 26-27, 2023, Montpellier, France

altCanbioSe Project Meeting and Project Workshop was held  at European Institute of Membranes (IEM), University of Montpellier, France on September 26-27, 2023. The workshop was focused on the theme of "Commercializing Biosensors, Intellectual Property, and Knowledge Transfer from Academia to Industry.

 
IEEE NAP 2023: 2023 IEEE 13th International Conference “Nanomaterials: Applications & Properties” Sep 10, 2023 - Sep 15, 2023, Bratislava, Slovakia

altDr. Oleksiy Gogotsi and Veronika Zahorodna visited IEEE NAP 2023 conference held in Bratislava on September 10-15, 2023. The prime focus of the IEEE NAP-2023 was on nanoscale materials with emphasis on interdisciplinary research exploring and exploiting their unique physical and chemical proprieties for practical applications.

 
Visit to CEST labs in Wiener Neustadt (Low Energy Ion Scattering, Batteries development) and TU Vienna (ELSA, SFA)

altDirector of MRC and Carbon-Ukraine Dr. Oleksiy Gogotsi visited CEST labs in Wiener Neustadt (Low Energy Ion Scattering, Batteries development) and TU Vienna (ELSA, SFA). He meet with Dr. Pierluigi Bilotto, Dr. Chriatian Pichler and their colleagues, discussing novel materials and r&d activities for new technologies.

 
MX-MAP Session at YUCOMAT Conference 2023 "Towards MXenes’ biomedical applications by high-dimensional immune MAPping", HORIZON-MSCA-2021-SE-01 project MX-MAP.

altMX-MAP Session was held during the YUCOMAT Conference 2023 titled: "Towards MXenes’ biomedical applications by high-dimensional immune MAPping", HORIZON-MSCA-2021-SE-01 project MX-MAP.

 
THE TWENTY-FOURTH ANNUAL CONFERENCE YUCOMAT 2023, HERCEG NOVI, MONTENEGRO, September 04-08, 2023

altThe conference was organised by the Materials Research Society of Sebia and supported by MRS-Singapore with the participation of a pleiad of distinguished scientists.

 
CANBIOSE secondment visit of Dr. Oleksiy Gogotsi and Veronika Zahorodna from MRC to European Institute of Membranes in Montpellier, France

altCANBIOSE project participants from MRC Dr. Oleksiy Gogotsi and Veronika Zahorodna performed secondment visit to project partner organization European Institute of Membranes in Montpellier (France) on August -September 2023.