Enhancing Electrochemical Glucose Biosensors with Ti₃C₂Tₓ MXenes
Diabetes remains one of the most significant global health challenges, affecting hundreds of millions of people worldwide. Continuous glucose monitoring is essential for effective disease management and prevention. In this study, researchers explored the potential of Ti₃C₂Tₓ MXenes as modifiers for the working electrode in electrochemical glucose biosensors, achieving substantial performance improvements compared to conventional designs.
The incorporation of Ti₃C₂Tₓ MXenes markedly enhanced sensor sensitivity and stability. The addition of Nafion or Aquivion as ionomer binders improved coating uniformity and layer adhesion, addressing issues of incomplete MXene coverage and surface instability. Optimization of polymer concentration proved essential for maintaining a balance between morphology, mechanical stability, and electrochemical activity. Among the redox mediators tested, phenazine methosulfate (PMS) demonstrated the most efficient electron transfer and superior overall sensor performance.
The resulting MXene-based biosensors exhibited:
A practical linear glucose detection range (0.1–5 mM)
Low limits of detection (23–48 μM)
High sensitivities (up to 97.5 μA mM⁻¹ cm⁻²)
Excellent repeatability and reproducibility
Importantly, the developed biosensors successfully detected glucose in human serum samples, confirming their practical applicability.
This work provides valuable insights into the use of pristine Ti₃C₂Tₓ MXenes (rather than composites) as promising materials for next-generation glucose biosensors. The study underscores the importance of surface chemistry, film stability, and polymer optimization in achieving high-performance sensing platforms. Future research should focus on exploring the effects of MXene deposition methods, flake size, and enzyme immobilization strategies to further improve analytical performance and ensure long-term stability in real-world biomedical applications.
MXenes potential applications include sensors, wound healing materials, and drug delivery systems. A recent study explored how different synthesis methods affect the safety and performance of MXenes. By comparing etching conditions and intercalation strategies, researchers discovered that fine-tuning the surface chemistry of MXenes plays a crucial role in improving biocompatibility. These results provide practical guidelines for developing safer MXenes and bring the field one step closer to real biomedical applications.
Exellent news, our joint patent application with Drexel University on highly porous MAX phase precursor for MXene synthesis published. Congratulations and thanks to all team involved!
Our team was very delighted to take part in International Symposium "The MXene Frontier: Transformative Nanomaterials Shaping the Future" – the largest MXene event in Europe this year! 
Last Call! Have you submitted your abstract for IEEE NAP-2025 yet? Join us at the International Symposium on "The MXene Frontier: Transformative Nanomaterials Shaping the Future" – the largest MXene-focused conference in Europe this year! Final Submission Deadline: May 15, 2025. Don’t miss this exclusive opportunity to showcase your research and engage with world leaders in the MXene field!
We are excited to announce the publication of latest review article on MXenes in Healthcare. This comprehensive review explores the groundbreaking role of MXenes—an emerging class of 2D materials—in revolutionizing the fields of medical diagnostics and therapeutics. Read the full article here: https://doi.org/10.1039/D4NR04853A.
Congratulations and thank you to our collaborators from TU Wien and CEST for very interesting work and making it published! In this work, an upscalable electrochemical MXene synthesis is presented. Yields of up to 60% electrochemical MXene (EC-MXene) with no byproducts from a single exfoliation cycle are achieved.
Congratulations to all collaborators with this interesting joint work!
Thank you to our collaborators for the amazing joint work recently published in Graphene and 2D Nanomaterials about MXene–silk fibroin composite films aiming to develop materials with tunable electronic and thermal properties
Dr. Oleksiy Gogotsi, director of MRC and Carbon-Ukraine, innovative companies that are among the leaders on the world MXene market, visited 2024 MRS Fall Meeting & Exhibit. together with Dr. Maksym Pogorielov, Head of Advanced Biomaterials and Biophysics Laboratory, University of Latvia.
MRC and Carbon-Ukraine team visited the 3rd International MXene conference held at Drexel University on August 5-8, 2024. Conference brought together the best reserchers and leading experts on MXene field. 
Together with colleagues from the University of Latvia, MRC/Carbone Ukraine, Adam Mickiewicz University, University Clinic Essen, and others, we have developed a novel concept involving the binding of antibodies to MXenes. In our research, we utilized anti-CEACAM1 antibodies to develop targeted photo-thermal therapy for melanoma (in vitro), paving the way for future in vivo studies and clinical trials. For the first time, we demonstrate the feasibility of delivering MXenes specifically targeted to melanoma cells, enabling the effective ablation of cancer cells under near-infrared (NIR) light. This new technique opens up vast potential for the application of MXenes in cancer treatment, diagnostics, drug delivery, and many other medical purposes.