Nanodiamonds for drug delivery and other biomedical applications

E-mail Печать PDF

 4th International Conference Nanobiophysics: Fundamental and Applied Aspects, 1-4 October 2015, Kyiv, Ukraine

 Nanodiamonds for drug delivery and other biomedical applications

O. Gogotsi1, Y. Gogotsi2, V. Mochalin2,  Y. Zozulya1, B. Malinovskiy1, V. Zahorodna1, I. Uvarova3, H. Gogotsi3,

1 Materials Research Centre, 3 Akademika Krzhyzhanovs'koho St, Kyiv 03680, Ukraine, E-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript
2 A. J. Drexel Nanomaterials Institute, and Department of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USA, E-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript
 3 Frantsevich Institute for Problems of Materials Science of NASU, 3 Akademika Krzhyzhanovs'koho St, Kyiv 03680, Ukraine, E-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript


     Carbon nanomaterials hold tremendous potential in addressing the two major issues faced by our society: providing energy and improving healthcare. Nanodiamond powder produced by detonation synthesis is one of the most promising carbon nanomaterials for drug delivery and theranostics [1], [2]. Diamond particles have a ~4-5 nm stable core and a large surface area with tailorable surface chemistry. Nanodiamonds have unique optical, mechanical and thermal properties. These properties have recently started to attract much interest for different biomedical applications [3]. Rich surface chemistry, nontoxicity and good biocompatibility of diamond nanoparticles make them attractive in biomaterial applications [4].
      The development of new methods for obtaining free nanodiamond particles opens up new possibility for targeted drug-delivery systems that overcome cell membranes, various biological markers, systems intended for determination of the concentration of bioactive agents in living organisms, and others applications [5]. For tissue engineering scaffolds, the non-toxic fluorescent nanodiamond introduced into biodegradable polymers provides increased strength, visual monitoring, and enhanced biomineralization [6].
Nanodiamond (ND) particles are increasingly being utilized as diagnostic, imaging, and therapeutic agents in biomedicine [7]. In the area of biomedical imaging and diagnostics, luminescent nanodiamond with NV centers, as well as chemically modified fluorescent nanodiamond, hold tremendous potential to replace toxic semiconductor quantum dots, thus bringing this exciting potential application one step closer to the clinics [8]. Before nanodiamonds could be applied, they have to undergo multistage purification, characterization and surface modification. Various approaches of surface modification and functionalization of nanodiamond allow to enhance and control drug adsorption for prolongation of drug action and chemical binding of the drugs for sustained drug release for their further use as a drug delivery platform. As for drug delivery, this study mainly focuses on adsorption of antibiotics that will be discussed in detail. We demonstrate results of physical−chemical study of the adsorption of doxorubicin, polymyxin B and rifampicin on nanodiamonds.

 [1]. V. Mochalin, O. Shenderova, D. Ho, Y. Gogotsi The Properties and Applications of Nanodiamonds (Review), Nature Nanotechnology, 7 (1), p.11-23 (2012)
[2]. V. Mochalin, A. Pentecost, X.-M. Li, I. Neitzel, M. Nelson, C. Wei, T. He, F. Guo, Y. Gogotsi Adsorption of Drugs on Nanodiamond: Toward Development of a Drug Delivery Platform, Molecular Pharmaceutics, 10 (10), p.3728-3735 (2013)
[3]. O. Shenderova, D. Gruen, ed. Detonation Nanodiamonds: Science and Applications (2nd Edition), CRC Press (2014)
[4]. Q. Zhang, V. Mochalin, I. Neitzel, I. Knoke, J. Han, C. Klug, J. Zhou, P. Lelkes, Y. Gogotsi, Fluorescent PLLA-nanodiamond composites for bone tissue engineering, Biomaterials, 32 (1), p. 87-94 (2011)
[5]. A. Schrand, S. Hens, O. Shenderova Nanodiamond particles: properties and perspectives for bioapplications, Critical Reviews in Solid State and Materials Sciences, 34(1–2), p. 18–74 (2009)
[6]. Q. Zhang, V. Mochalin, I. Neitzel, K. Hazeli, J. Niu, A. Kontsos, J. G. Zhou, P. I. Lelkes, Y. Gogotsi Multifunctional Nanodiamond-PLLA Scaffolds for Bone Tissue Engineering: Enhanced Mechanical Strength and Biomineralization, Biomaterials, 33 (20), p.5067-5075 (2012)
[7]. V. Vaijayanthimala, D. Lee, S. Kim, A. Yen, D. Tsai, H.-C. Chang, O. Shenderova Nanodiamond-mediated drug delivery and imaging: challenges and opportunities, Expert Opinion on Drug Delivery 12 (6), p. 1-15 (2014)
[8]. G. Balasubramanian, A. Lazariev, S. R. Arumugam, et al. Nitrogen-Vacancy color center in diamond-emerging nanoscale applications in bioimaging and biosensing. Current Opinion in Chemical Biology 20, p. 69-77 (2014)

Download PDF version of Nanodiamonds for drug delivery and other biomedical applications 

Here you can find Book of Abstract of the Conference NBP 2015


News from MRC.ORG.UA

If you want to help and support the purchase of aid consignments, shipping cost to Ukraine and delivery within Ukraine to the places in nee, please donate

Our volunteersBig thanks to all our friends, partners, volunteers for help and their tireless work! We continue to help our defenders and deliver military equipment, humanitarian aid, tactical medicine and special medical supplies to units of Ukrainian Army, territorial defense and hospitals on the front line!

Delivering help to Ukraine from the USA, Europe, and the rest of the world!

3.jpg - 197.81 KbOur organization in Kyiv, Materials Research Center, is well aware of the needs in Ukraine now. Together with our partners, fellow Ukrainian scientists, we have organized a warehouse in Lviv, where we collect cargos and distribute them throughout Ukraine, with detailed reports confirming the delivery to the final destination, including photos of the transfer. We have transportation that can pick cargo in Poland and deliver it through a green corridor for humanitarian cargos at the Polish-Ukrainian border. 
We are ready to respond promptly, as required by the situation in Ukraine. If there are individuals, foundations or volunteer organizations willing to send help to Ukraine from Europe or the United States, we are ready to accept it in our warehouses, make collection or individual parties according to your request and pass them on to those in need. All humanitarian aid, first aid, and protective gear will be delivered to the final destination.
Please contact Dr. Oleksiy Gogotsi, MRC Director: Tel / Viber / WhatsApp / Telegram / Signal: + 380 63 233 2443, Cell phone in the USA: +1 808 203 8092, e-mail:
Being currently on a business trip in Philadelphia, the United States, we can meet with you in person, if needed.

MRC Ukraine Foundation. Providing of military first aid medicine for the Special Operations Forces of the Armed Forces of Ukraine


MRC Ukraine Foundation. Providing of military first aid medicine for the Special Operations Forces of the Armed Forces of Ukraine via volunteers. Specialized military first aid medical supplies were provided by the Special Forces Foundation, Green Berets Humanitarian Fund, USA

Delivering military first aid medicine from the Special Forces Foundation Green Beret Humanitarian Fund (GBHF) from the USA to territorial defences, army unit and 2 hospitals


Delivering military first aid medicine from the Special Forces Foundation Green Beret Humanitarian Fund (GBHF) from the USA via the Kernel Volunteer Group for the Territorial Defense of Kyiv, Poltava, Vinnytsia, Voznesensk, as well as some military unit in Kyiv and Ternopil. Also part of medical supplies is transferred to hospitals in Krasnopillia in Sumy region and Voznesensk in Mykolaiv region


MRC Ukraine Foundation. Transfer of military first aid medicine at our hub in Lviv


MRC Ukraine Foundation. Transfer of military first aid medicine at our hub in Lviv from the American Green Beret Humanitarian Fund for some military units.

BSU and LU parthers secondment visits to MRC an seminar discussion of ongoing research works under the NANO2DAY project at Materials Research Center, February 2022


During the secondment visits of project partners from BSU and LU to MRC research works were performed and a seminar discussion of ongoing research works and obtained results was held under the NANO2DAY project.

Registration is now open for the upcoming MXene Certificate Course, February 7-11, 2022 from Professor Yury Gogotsi and his team, Drexel University, USA

altRegistration is now open for the upcoming MXene Certificate Course, February 7-11, 2022! This virtual certificate course will teach best practices for the synthesis (2 days), characterization (2 days), and electrochemical measurements of MXenes with a new lecture in the biomedical applications of MXenes (you may choose electrochemical measurements OR biomedical applications - 1 day).

Visiting resracher S. Stankevich performed secondment to MRC due to NANO2DAY project

altStanislav Stankevich, research assistant from Latvias University, Riga, Latvia, performed secondment visit to Materials Research Center, Kyiv, Ukraine, due to the MSCA RISE research project NANO2DAY working on project tasks related to MXene based composites. Dates of performed secondment visit November 17-December 16, 2021.

2021 IEEE 11th International Conference on "Nanomaterials: Applications & Properties" (NAP-2021)


Director of Materials Research Center Dr. Oleksiy Gogotsi and young researcher Veronika Zahorodna visited NAP-2021 conference on nanomaterials held on September 05-11, 2021 in Odessa, Ukraine.

The prime focus of this conference, held annually since 2011, is on the nanoscale materials with emphasis on interdisciplinary research exploring and exploiting unique physical and chemical properties of these materials for practical applications.

Drexel's MXene Filter Materials will be used for Wearable Artificial Kidney Technology

MXene pores“Our fundamental study of titanium carbide MXene supported by NSF showed that MXene is biocompatible, able of adsorbing a variety of small molecules, and holds a lot of promise in medical applications, so it is exciting to see it applied for improving and really changing dialysis — an area of need in health care that can help millions of people,” said Yury Gogotsi, PhD, Distinguished University and Bach professor in Drexel’s College of Engineering, who is a world leader in developing and studying MXenes.

22nd Annual Conference on Material Science - YUKOMAT 2021, Herceg Novi, Montenegro, on August 30 – September 05, 2021

altMRC team members Dr.Oleksiy Gogotsi and Veronika Zahorodna visited 22rd Annual Conference on Material Science - YUKOMAT 2021.

MXene Coating Could Prevent Electromagnetic Interference in Wearable Devices

mxene-emi-fabricResearchers at Drexel University’s College of Engineering have reported that MXene coated fabric is highly effective for blocking electromagnetic waves and potentially harmful radiation. The discovery is a key development for efforts to weave technological capabilities into clothing and accessories. 

MRC and Drexel collaborative article on Scalable MXene synthesis is listed among the most accessed in Advanced Engineering Materials journal for the whole year

bulk MXene

This article is also Highly Cited in Web of Science (top 1% of all papers in the field).

H2020 MSCA RISE CanBioSe project activities - EsR/ER training and scientific seminar held in MRC, Kyiv, Ukraine, July 30-August 01, 2020

Canbiose project training and seminar

Training of early-staged researchers involved in CanBioSe research works on nanomaterials processing and scientific seminar on Advances in nanomaterials research for biomedical applications, were held with invited experts.

Scalable Production System for the Promising, 2D Nanomaterials MXenes

altFor one of the most promising new types of 2D nanomaterials, MXenes, that’s no longer a problem. Researchers at Drexel University and the Materials Research Center in Ukraine have designed a system that can be used to make large quantities of the material while preserving its unique properties