Nanodiamonds for drug delivery and other biomedical applications

E-mail Печать PDF

 4th International Conference Nanobiophysics: Fundamental and Applied Aspects, 1-4 October 2015, Kyiv, Ukraine

 Nanodiamonds for drug delivery and other biomedical applications

O. Gogotsi1, Y. Gogotsi2, V. Mochalin2,  Y. Zozulya1, B. Malinovskiy1, V. Zahorodna1, I. Uvarova3, H. Gogotsi3,

1 Materials Research Centre, 3 Akademika Krzhyzhanovs'koho St, Kyiv 03680, Ukraine, E-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript
2 A. J. Drexel Nanomaterials Institute, and Department of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USA, E-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript
 3 Frantsevich Institute for Problems of Materials Science of NASU, 3 Akademika Krzhyzhanovs'koho St, Kyiv 03680, Ukraine, E-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript


     Carbon nanomaterials hold tremendous potential in addressing the two major issues faced by our society: providing energy and improving healthcare. Nanodiamond powder produced by detonation synthesis is one of the most promising carbon nanomaterials for drug delivery and theranostics [1], [2]. Diamond particles have a ~4-5 nm stable core and a large surface area with tailorable surface chemistry. Nanodiamonds have unique optical, mechanical and thermal properties. These properties have recently started to attract much interest for different biomedical applications [3]. Rich surface chemistry, nontoxicity and good biocompatibility of diamond nanoparticles make them attractive in biomaterial applications [4].
      The development of new methods for obtaining free nanodiamond particles opens up new possibility for targeted drug-delivery systems that overcome cell membranes, various biological markers, systems intended for determination of the concentration of bioactive agents in living organisms, and others applications [5]. For tissue engineering scaffolds, the non-toxic fluorescent nanodiamond introduced into biodegradable polymers provides increased strength, visual monitoring, and enhanced biomineralization [6].
Nanodiamond (ND) particles are increasingly being utilized as diagnostic, imaging, and therapeutic agents in biomedicine [7]. In the area of biomedical imaging and diagnostics, luminescent nanodiamond with NV centers, as well as chemically modified fluorescent nanodiamond, hold tremendous potential to replace toxic semiconductor quantum dots, thus bringing this exciting potential application one step closer to the clinics [8]. Before nanodiamonds could be applied, they have to undergo multistage purification, characterization and surface modification. Various approaches of surface modification and functionalization of nanodiamond allow to enhance and control drug adsorption for prolongation of drug action and chemical binding of the drugs for sustained drug release for their further use as a drug delivery platform. As for drug delivery, this study mainly focuses on adsorption of antibiotics that will be discussed in detail. We demonstrate results of physical−chemical study of the adsorption of doxorubicin, polymyxin B and rifampicin on nanodiamonds.

 [1]. V. Mochalin, O. Shenderova, D. Ho, Y. Gogotsi The Properties and Applications of Nanodiamonds (Review), Nature Nanotechnology, 7 (1), p.11-23 (2012)
[2]. V. Mochalin, A. Pentecost, X.-M. Li, I. Neitzel, M. Nelson, C. Wei, T. He, F. Guo, Y. Gogotsi Adsorption of Drugs on Nanodiamond: Toward Development of a Drug Delivery Platform, Molecular Pharmaceutics, 10 (10), p.3728-3735 (2013)
[3]. O. Shenderova, D. Gruen, ed. Detonation Nanodiamonds: Science and Applications (2nd Edition), CRC Press (2014)
[4]. Q. Zhang, V. Mochalin, I. Neitzel, I. Knoke, J. Han, C. Klug, J. Zhou, P. Lelkes, Y. Gogotsi, Fluorescent PLLA-nanodiamond composites for bone tissue engineering, Biomaterials, 32 (1), p. 87-94 (2011)
[5]. A. Schrand, S. Hens, O. Shenderova Nanodiamond particles: properties and perspectives for bioapplications, Critical Reviews in Solid State and Materials Sciences, 34(1–2), p. 18–74 (2009)
[6]. Q. Zhang, V. Mochalin, I. Neitzel, K. Hazeli, J. Niu, A. Kontsos, J. G. Zhou, P. I. Lelkes, Y. Gogotsi Multifunctional Nanodiamond-PLLA Scaffolds for Bone Tissue Engineering: Enhanced Mechanical Strength and Biomineralization, Biomaterials, 33 (20), p.5067-5075 (2012)
[7]. V. Vaijayanthimala, D. Lee, S. Kim, A. Yen, D. Tsai, H.-C. Chang, O. Shenderova Nanodiamond-mediated drug delivery and imaging: challenges and opportunities, Expert Opinion on Drug Delivery 12 (6), p. 1-15 (2014)
[8]. G. Balasubramanian, A. Lazariev, S. R. Arumugam, et al. Nitrogen-Vacancy color center in diamond-emerging nanoscale applications in bioimaging and biosensing. Current Opinion in Chemical Biology 20, p. 69-77 (2014)

Download PDF version of Nanodiamonds for drug delivery and other biomedical applications 

Here you can find Book of Abstract of the Conference NBP 2015


News from MRC.ORG.UA

Drexel's MXene Filter Materials will be used for Wearable Artificial Kidney Technology

MXene pores“Our fundamental study of titanium carbide MXene supported by NSF showed that MXene is biocompatible, able of adsorbing a variety of small molecules, and holds a lot of promise in medical applications, so it is exciting to see it applied for improving and really changing dialysis — an area of need in health care that can help millions of people,” said Yury Gogotsi, PhD, Distinguished University and Bach professor in Drexel’s College of Engineering, who is a world leader in developing and studying MXenes.

MXene Coating Could Prevent Electromagnetic Interference in Wearable Devices

mxene-emi-fabricResearchers at Drexel University’s College of Engineering have reported that MXene coated fabric is highly effective for blocking electromagnetic waves and potentially harmful radiation. The discovery is a key development for efforts to weave technological capabilities into clothing and accessories. 

MRC and Drexel collaborative article on Scalable MXene synthesis is listed among the most accessed in Advanced Engineering Materials journal for the whole year

bulk MXene

This article is also Highly Cited in Web of Science (top 1% of all papers in the field).

H2020 MSCA RISE CanBioSe project activities - EsR/ER training and scientific seminar held in MRC, Kyiv, Ukraine, July 30-August 01, 2020

Canbiose project training and seminar

Training of early-staged researchers involved in CanBioSe research works on nanomaterials processing and scientific seminar on Advances in nanomaterials research for biomedical applications, were held with invited experts.

Scalable Production System for the Promising, 2D Nanomaterials MXenes

altFor one of the most promising new types of 2D nanomaterials, MXenes, that’s no longer a problem. Researchers at Drexel University and the Materials Research Center in Ukraine have designed a system that can be used to make large quantities of the material while preserving its unique properties

CANBIOSE project participant from MRC completed secondment visit to partner organization Vilnius University, Lithuania, on February-March 2020 due to CANBIOSE project

altCANBIOSE project participant from MRC performed secondment visit to project partner organization Vilnius University, Lithuania, on February 24 - March 14 2020.

H2020 MSCA RISE SALSETH project participant from MRC V. Balitskiy started secondment at University of Novi Sad, Serbia

altSALSETH project participant from MRC Vitalii Balitskiy was hosted by partners from University of Novi Sad (UNS), Serbia, during his secondment visit according to the project plan.

SALSETH Project Kick-off meeting was held in University of Novi Sad, Serbia, on february 28, 2020

altResearch team from Materials Research Centre (MRC), Kyiv, Ukraine, was represented by Vitalii Balitskiy, who made a presentation to project partners about the MRC company, its capabilities, current research projects and main activities.

The science of the future and the use of intelligent nanomaterials in advanced technologies. Lecture by Professor Yury Gogotsi for students, schoolchildren of Junior Academy of Sciences of Ukraine in Igor Sikorsky Kyiv Polytechnic Institute,Feb 24, 2020


The science of the future and the use of smart nanomaterials in new technologies. Lecture by Professor Yury Gogotsi for students, and schoolchildren of the Junior Academy of Sciences of Ukraine in Sikorsky Kyiv Polytechnic Institute, February 27, 2020

Horizon 2020 NANO2DAY project participant A.Stepura from Polymer Institute of Slovak Academy of Science (Bratislava, Slovakia) was hosted by Materials Research Center (MRC), Kiev, Ukraine, on December 2019-February 2020

pisas--secondment-to-mrc-jan-2020_13.jpg - 86.27 KbAnastasiia Stepura from Polymer Institute Slovak Academy of Science (Bratislava, Slovakia) was hosted by Materials Research Centre  on December 2019- February 2020 during her secondment performing research works due to H2020 NANO2DAY project.

H2020 NANO2DAY project participants from MRC Veronika Zahorodna and Oleksiy Gogotsi visited partner organization Polymer Instityte SAS, Bratislava, Slovakia on January 2020

altResearchers from the Materials Research Center (MRC), Kiev, Ukraine,  Oleksiy Gogotsi and Veronika Zahorodna visited Horizon 2020 NANO2DAY project partner organization Polymer Institute of Slovak Academy of Science, Bratislava, Slovakia on January 2020. In cooperation with PISAS colleagues they were working on MXene doped polymer nanocomposites.

H2020 NANO2DAY project participant from MRC Ivan Hryshko was visiting project partner organization University of Latvia, Riga, on November-December 2019

altResearch engineer from MRC Ivan Hryshko is being visiting the University of Latvia, where he held a seminar on MXenes

Secondment of project participants from MRC O. Gogotsi and V. Zahorodna to project partners from LNEC under Horizon 2020 MSCA RISE Project №690968 NANOGUARD2AR, 12/11-11/12/2019, Lisboan, Portugal

altMRC Director O. Gogotsi and EsR Veronika Zahorodna in a secondment to LNEC, Lisboan, Portugal participated in a work meeting discussing project results and performing engineering research works due to H2020 MSCA RISE project No 690968 NANOGUARD2AR.

Horizon 2020 CANBIOSE project participants from Materials Research Center (MRC), Kiev, Ukraine visited partner organization Adam Mickiewicz University in Poznań, Poland, on October 27-November 27, 2019

altIn cooperation with AMU colleagues they were working on nanomaterials testing and characterization.


altThe symposium brought together leading international experts and those researchers who are just entering the exciting world of 2D carbides and nitrides to explore new synthesis methods, better understand properties and find new applications of MXenes.