International Conference on Nanomaterials for biosensors and biomedical applications, Jurmala, Latvia
MRC representatives, Oleksiy Gogotsi and Veronika Zahorodna attended CanBioSe project meeting held during International Conference on Nanomaterials for biosensors and biomedical applications, Jurmala, Latvia, on July 2019.
MRC director Oleksiy Gogotsi made an oral presentaion on MXenes for biosensors and biomedical applications.
MXenes for biosensors and biomedical applications
Oleksiy Gogotsia, b, Veronika Zahorodnaa, b, Vitalii Balitskyia, , Mykola Seredych c, Qi Zhao c, Yury Gogotsi c
a Materials Research Centre, Kyiv 03680, Ukraine
b National Metallurgical Academy of Ukraine, Dnipro 49600, Ukraine
c Department of Materials Science & Engineering and A.J. Drexel Nanomaterials Institute, Drexel University, Philadelphia, Pennsylvania 19104, United States
2-Dimensional transition metal carbides and nitrides (MXenes) - discovered at Drexel University [1] hold tremendous potential as new materials for biomedial applications. MXenes are produced by selective etching of the A elements (mostly Al) from their ternary layered 3D Mn+1AXn, phase counterparts, where M is an early transition metal, A is an A-group element, X is C and/or N, and n = 1 to 3 [2]. In contrast to raw Mn+1AXn phases, the MXene sheets are oxygenated (═O, −OH) and fluorinated (–F) for preferential sorption of target biomolecules. Beyond the characteristics shared by all 2D materials, MXenes stand out in several ways. They are: i) conductive, with high density of states at the Fermi level and metal-like carrier densities; ii) hydrophilic, and thus processable in eco-friendly and sustainable ways; iii) extraordinarily and readily tailorable at multiple levels. MXenes have already shown promising performance in many applications includingdrug delivery and photothermal therapy [3], antibacterial activity [4], electrodes and sensors for medicine [5, 6],selective sorption of small molecules such as urea removal in wearable dialysis systems [7]. Moreover, cytotoxic tests show no significant effect on cell viability during 24 h incubation with 3T3 fibroblast cells by the titanium carbide MXenes [7]. This kind of MXenes sorbents offer open accessible surfaces fully available for proteins and can also be used in treatment of a broad range of conditions ranging from radiation disease and drug overdose to Ebola, Crohn’s disease, Ankylosing Spondylitis and other conditions related to cytokines or toxin in blood.
References
[1] M. Naguib, et al. Two-dimensional nanocrystals produced by exfoliation of Ti3AlC2. Advanced Materials 2011, 23, 4248.
[2] B. Anasori, et al. 2D metal carbides and nitrides (MXenes) for energy storage. Nature Review Materials 2017, 16098, 1.
[3] C. Dai, et al. Two-dimensional tantalum carbide (MXenes) composite nanosheets for multiple imaging-guided photothermal tumor ablation. ACS Nano 2017, 11, 12696.
[4] K.Rasool, et al. Antibacterial activity of Ti3C2Tx MXene. ACS Nano 2016, 10, 3674.
[5] N. Driscoll, et al. Two-dimensional Ti3C2 MXene for high-resolution neural interfaces
ACS Nano 2018, 12, 1041.
Abstract book of the Conference
Here we demonstrate a new developed method for depositing Ti3C2Tx MXenes onto hydrophobic electrospun PCL membranes using oxygen plasma treatment. These novel patches hold tremendous potential for providing mechanical support to damaged heart tissue and enabling electrical signal transmission,thereby mimicking the crucial electroconductivity required for normal cardiac function. After a detailed investigation of scaffold-to-cell interplay, including electrical stimulation, novel technology has the potential for clinical application not only for cardiac regeneration, but also as neural and muscular tissue substitutes.
MX-MAP project participants from MRC Dr. Oleksiy Gogotsi and Veronika Zahorodna performed split secondment visit to project partner organization University of Padova (Italy). MX-MAP project works on development of the key strategies for MXene medical applications. 
CanbioSe Project Meeting and Project Workshop was held at European Institute of Membranes (IEM), University of Montpellier, France on September 26-27, 2023. The workshop was focused on the theme of "Commercializing Biosensors, Intellectual Property, and Knowledge Transfer from Academia to Industry.
Dr. Oleksiy Gogotsi and Veronika Zahorodna visited IEEE NAP 2023 conference held in Bratislava on September 10-15, 2023. The prime focus of the IEEE NAP-2023 was on nanoscale materials with emphasis on interdisciplinary research exploring and exploiting their unique physical and chemical proprieties for practical applications.
Director of MRC and Carbon-Ukraine Dr. Oleksiy Gogotsi visited CEST labs in Wiener Neustadt (Low Energy Ion Scattering, Batteries development) and TU Vienna (ELSA, SFA). He meet with Dr. Pierluigi Bilotto, Dr. Chriatian Pichler and their colleagues, discussing novel materials and r&d activities for new technologies.
MX-MAP Session was held during the YUCOMAT Conference 2023 titled: "Towards MXenes’ biomedical applications by high-dimensional immune MAPping", HORIZON-MSCA-2021-SE-01 project MX-MAP.
CANBIOSE project participants from MRC Dr. Oleksiy Gogotsi and Veronika Zahorodna performed secondment visit to project partner organization European Institute of Membranes in Montpellier (France) on August -September 2023.
MRC researchers Dr. Oleksiy Gogotsi and Veronika Zahorodna were visiting Nanobiomedical Centre, Adam Mickewicz University in Poznan, Poland due to close collaboration with AMU team led by Dr. Igor Iatsunskiy. 
Meeting during the MXene international conference held in Drexel University on Aug. 3, 2022, and discussing the roadmap for launching MX-MAP research project on MXenes for medical applications.