Multifunctional carbon-nanotube cellular endoscopes

cellular endoscope

A Drexel University team of engineers, scientists and biologists have developed a carbon nanotube-based device for probing single living cells without damaging them. ...

 

Multifunctional carbon-nanotube cellular endoscopes

Artist renderings of a nano-needle poking a single cell have become the symbol of nanotechnology, surfacing on covers of magazines and books for about a decade but actual nano-needles able to interrogate small cells without causing cellular damage have not become reality until recently. A Drexel University team of engineers, scientists and biologists have developed a carbon nanotube-based device for probing single living cells without damaging them. This technique will allow experts to identify diseases in their early stage and advance drug discovery.
The research led by Dr. Yury Gogotsi, professor of materials science and engineering and director of the A.J. Drexel Nanotechnology Institute (DNI) , and Dr. Gary Friedman, professor of electrical engineering, uses the nanotube-based device, known as a cellular endoscope, to evaluate cells about a thousand times smaller than a human hair. The cellular endoscope interrogates the intracellular environment of living cells, delivers fluorescent quantum dots and analyzes molecules inside a cell without the cell recognizing the needle’s presence.

cellular probe

“Drexel’s W. M. Keck Institute for Attofluidic Probes now manufactures the smallest endoscopes ever created,” Gogotsi said. “Endoscopes provide a potentially transformative technology for studying the fundamentals of single living cells and more broadly, for cell biology.”
Cell biologists usually destroy a large number of cells to extract cellular components and biological molecules needed for identifying diseases and analyzing effects of new drugs, or to achieve a better understanding of how the cell functions. Glass pipettes are widely used to inject material into cells. The pipettes cause too much damage to remain within the cell for a long time and are not designed to report information in the form of optical or electrical signals from within the cell.

cell-interrogation-by-endoscope

“We had an idea for a minimally invasive cellular probe, the tip of which could remain within the cell for a long time while reporting important information in the form of optical and electrical signals and transferring tiny amounts of material to and from the cell. This probe is similar to an endoscope employed by doctors to perform minimally invasive operations inside human patients, only much smaller” said Friedman. “A cellular endoscope reported here is a novel, but conceptually simple device,” said Riju Singhal, a doctoral candidate and author of the article “Multifunctional carbon-nanotube cellular endoscopes” published in the Nature Nanotechnology journal.
“It consists of a single carbon nanotube connected to the tips of larger glass micropipettes that are commonly employed in biological studies, enabling them to become widely used in the near future,” said Singhal.
Dr. Michael Schrlau, research assistant professor in Drexel’s Material Science and Engineering who directs the research laboratory of the W. M. Keck Institute, said, “We’re now building upon the multiple demonstrated functions of cellular endoscopes to help answer elusive cell biological questions. One application of cellular endoscopes being actively pursued is intracellular surface-enhanced Raman spectroscopy with gold-coated endoscopes.”

The Drexel team is funded by the Nanoscale Interdisciplinary Research Team National Science Foundation grant and the W. M. Keck Foundation.

Reference:

Singhal, R., Orynbayeva, Z., Kalyana Sundaram, R., Niu, J., Bhattacharyya, S., Vitol, E., Schrlau, M., Papazoglou, E., Friedman, G., & Gogotsi, Y. Multifunctional carbon-nanotube cellular endoscopes. Nature Nanotechnology 6 (2011) 57–64, DOI: 10.1038/nnano.2010.241

Drexel Researchers Create Early Disease Detection and Drug Delivery Device for Single Living Cells// http://www.drexel.edu/news/headlines/drexel-researchers-create-early-disease-detection-and-drug-delivery-device-for-single-living-cells.aspx

 

News from MRC.ORG.UA

US-Czech Conference on Advanced Nanotechnology and Chemistry 17 th – 18th January 2018, Prague, Czech

US-Czeh conference on advanced nanotechnologiesMore than 30 speakers from USA and Czech were invited, among them also was invited outstanding scientist, professor Yury Gogotsi, founder director of Drexel Nanomaterials Institute in Drexel University, USA.

 
ICEnSM 2017. 2017 International Conference on Energy Storage Materials, Shenzhen, China, November 18-21, 2017

The First International Conference on Energy Storage Materials Professor Yury Gogotsi from Drexel University, USA, has won the 2017 Energy Storage Materials Award, which is awarded by the journal Energy Storage Materials. The Award will be presented to Professor Gogotsi at the ICEnSM 2017 (2017 International Conference on Energy Storage Materials), which will be held in Shenzhen, China, on Nov. 18-21, 2017.

 
Congratulations to professor Yury Gogotsi for being named 2017 Highly Cited Researcher in two categories!

altHis research ranks among the top 1% most cited works in his field and during its year of publication, earning the mark of exceptional impact. This year is the first time Yury Gogotsi made this list in two categories - Materials Science and Chemistry.

 
Nanodiamonds Can Prevent Lithium Battery Fires
 
Congrats to professor Yury Gogotsi on winning the 2017 Changbai Mountain Friendship Award

Receiving a Changbai Mountain Friendship Award from the vice-governor of Jilin Province at the National Day foreign experts reception.Professor Yury Gogotsi from Drexel University, USA, received the 2017 Changbai Mountain Friendship Award from the vice-governor of Jilin Province at the National Day foreign experts reception.

 
Congarstulations to professor Yury Gogotsi from Drexel University, USA, who has won the 2017 Energy Storage Materials Award

yury gogotsiCongarstulations to professor Yury Gogotsi from Drexel University, USA, who has won the 2017 Energy Storage Materials Award,and is awarded by Energy Storage Materials journal.

 
Partial breaking of the Coulombic ordering of ionic liquids confined in carbon nanopores

An international team of researchers, including Drexel's Yury Gogotsi, PhD, observed that ions will forgo their typical alternating charge ordering when they are forced to jam into a small, sub-nanometer-sized, space — a behavior modification not unlike people relinquishing personal space in order to pack into a crowded subway car. The discovery could lead to safer energy storage devices and better water filtration membranes.In their most recent paper in Nature Materials researcher from Drexel University led by prof. Yury Gogotsi showed that Coulombic ordering reduces when the pores can accommodate only a single layer of ions. The non-Coulombic ordering is further enhanced in the presence of an applied electric potential. 

 
Researcers from Drexel University have developed a recipe that can turn electrolyte solution into a safeguard against the chemical process that leads to battery-related disasters

Recipe for Safer Batteries — Just Add DiamondsResearchers described a process by which nanodiamonds — tiny diamond particles 10,000 times smaller than the diameter of a hair — curtail the electrochemical deposition, called plating, that can lead to hazardous short-circuiting of lithium ion batteries.

 
Triangle Talks with Yury Gogotsi

alt

Yury Gogotsi is a researcher in the Drexel University Nanomaterials Group. He and his colleagues discovered a series of novel materials known as MXenes. 

 
Yury Gogotsi is the most influential scientist of modern Ukraine

altThe life of Yury Gogotsi is a constant back and forth between the top laboratories in the world, writing articles in the best scientific journals and research materials that can change the world around them. 

 
Professor Yury Gogotsi , Drexel University, USA, received an Honorary Doctorate from Frantsevich Institute for Problems of Materials Science, National Academy of Science of Ukraine, Kiev, Ukraine, June 20, 2017.

Deputy Directors of IPMS NAS professors Dr. Ragulya, Dr. Baglyuk, Mr. Zavorotnyi, Honorary Professor of IPMS NASU Yury Gogotsi,  Scientific Secretary Dr. Kartuzov and Dr. Firstov Professor Yury Gogotsi , Drexel University, USA,  received an Honorary Doctorate from Frantsevich Institute for Problems of Materials Science, National Academy of Science of Ukraine.

 
Professor Yury Gogotsi was speaking about nanotechnology in energy storage at the World Science Festival 2017

Professor Yury Gogotsi at World Science Festival 2017Join world-class nanoscientists and environmental leaders to explore how the capacity to harness molecules and atoms is accelerating spectacular inventions — including light-weight “wonder materials,” vital energy-storage technologies, and new sources of renewable energy — which promise to redefine the very future of energy.

 
MXenes are at the forefront of 2D materials research

alt

Research of 2D MXenes is prominently featured in an article in Chemical & Engineering News - bulletin of the American Chemical Society that goes in hard copy to more than 150,000 subscribers. No doubt, MXenes are at the forefront of 2D materials research.

 
IDEATION Seminars: A New Platform for Innovation Management, Promotion, Licensing, Technology Transfer and Commercialization, June 7 at 14:30, KPI, Kyiv

altSpeakers:  Victor Korsun and Douglas Graham

 
Nano Iguana became a 1st place winner at 2017 MRS Science as Art Competition

Entry Nano Iguana became a 1st place winner at Science as Art Competition 2017: Nano-anatase (TiO2) crystals decorating graphene-like carbon, fabricated by oxidizing 2d Ti3C2 MXene powder, presented by A. J. Drexel Nanotechnology Institute and Department of Materials Science  and Engineering, Drexel University, USAResearch team from Drexel University lead by professor Yury Gogotsi produced an award-wining entry and became the 1st place winner in Science as Art competition at 2017 MRS Spring meeting in Phoenix.